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316,317,318 Lactate-induced extracellular acidosis blocks one-carbon metabolism that short-lived effector T cells are highly dependent on, subsequently bringing about decreased histone 3 lysine 27 trimethylation (H3K27me3) deposition of memory-related genes, thereby affecting differentiation, reserving sternness and facilitating anti-tumor cytotoxicity of T cells

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Tirzepatide (Zepbound, FDA-approved for weight management) functions as both a GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist

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[DOI] [PubMed] [Google Scholar] 325.Korshunov S.S., Skulachev V.P., Starkov A.A